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Merkel cell carcinoma is a rare but aggressive neuroendocrine tumor of the skin with high propens...

期刊:Radiol Case Rep  影响因子:0.0  发表日期: 20070101  PMID: 27303490 




The programmed cell death protein 1 (PD-1) pathway has received considerable attention due to its...

关键词: 5-AZA-dC, 5-aza-2′-deoxycytidine    ADCC, Antibody-dependent cellular cytotoxicity    AEs, Adverse events    AP1, Activator protein 1    APCs, Antigen presenting cells    ASCT, Autologous stem cell transplantation    B2M, β2 microglobulin    BATF, Basic leucine zipper transcriptional factor ATF-like    BICR, Blinded Independent Central Review    BV, Brentuximab vedotin    CC, Cervical cancer    CRC, Colorectal cancer    CTLA-4, Cytotoxic T-lymphocyte–associated antigen 4    CXCL9, C-X-C motif chemokine ligand 9    Checkpoint blockade    DCM, Dilated cardiomyopathy    DCs, Dendritic cells    DNMT, DNA methyltransferase    DOR, Duration overall response    DZNep, 3-Deazaneplanocin A    ERK, Extracellular signal–regulated kinase    EZH2, Enhancer of zeste homolog 2    GC, Gastric cancer    GEJ, GASTRIC or gastroesophageal junction    HCC, Hepatocellular carcinoma    HNSCC, Head and neck squamous cell carcinoma    HR, Hazard ratio    ICC, Investigator-choice chemotherapy    ICOS, Inducible T-cell co-stimulator    IFN, Interferon    IHC, Immunohistochemistry    ITIM, Immune-receptortyrosine-based inhibitory motif    ITSM, Immune-receptortyrosine-based switch motif    ITT, Intention-to-treat    Immune surveillance    Immunotherapy    IrAEs, Immune related adverse events    JMJD3, Jumonji Domain-Containing Protein 3    LAG3, Lymphocyte-activation gene 3    LCK, Tyrosine-protein kinase Lck    MAP, Mitogen-activated protein    MCC, Merkel cell carcinoma    MHC, Major histocompatibility    MSI-H, Microsatellite instability-high    NF-κB, Nuclear factor-κB    NFAT, Nuclear factor of activated T cells    NSCLC, Non-small cell lung cancer    ORR, Overall response rate    OS, Overall survival    PD-1    PD-1, Programmed cell death 1    PD-L1    PD-L1, Programmed death-ligand 1    PFS, Progression-free survival    PI3K, Phosphoinositide 3-kinase    PKC, Protein kinase C    PMBCL, Primary mediastinal large B-cell lymphoma    PRC2, Polycomb repressive complex 2    PTEN, Phosphatase and tensin homolog    PTPs, Protein tyrosine phosphatases    RCC, Renal cell carcinoma    SCLC, Small cell lung cancer    SHP2, Src homology 2 domain-containing phosphatase 2    SIRPα, Signal-regulatory protein alpha    TCR, T-cell receptor    TGF, Transforming growth factor    TIICs, Tumor infiltrating immune cells    TILs, Tumor-infiltrating lymphocytes    TIM3, T-cell immunoglobulin and mucin-domain containing-3    TMB, Tumor mutation burden    TME, Tumor microenvironment    UC, Urothelial carcinoma    VEGF, Vascular endothelial growth factor    ZAP70, Zeta-chain-associated protein kinase 70    cHL, Classical Hodgkin lymphoma    cTnI, Cardiac troponin I    dMMR, DNA mismatch repair deficiency   
期刊:Comput Struct Biotechnol J  影响因子:4.72  发表日期: 20190101  PMID: 31205619 






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