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期刊:JAAD Case Rep  影响因子:0.0  发表日期: 20150701  PMID: 27051735 






Process changes are inevitable in the life cycle of recombinant monoclonal antibody therapeutics....

关键词: ADA, Anti-drug antibodies    ADCC, Antibody-dependent cell-mediated cytotoxicity    AGE, Advanced glycation end products    Arg, Arginine    Asn, Asparagine    Asp, Aspartate    C1q, The first component of complement    CD, Circular dichroism    CDC, Complement-dependent cytotoxicity    CDR, Complementarity-determining regions    CH2, Constant domain 2    CHO, Chinese hamster ovary    CQA, critical quality attributes    CZE, Capillary zone electrophoresis    Cys, Cysteine    DSC, Differential scanning calorimetry    EMA, European Medicines Agency    FDA, US Food and Drug Administration    Fab, Antigen-binding fragments    Fc, Fragment crystallizable region    FcRn, Neonatal Fc receptor    FcƳR, Fc gamma receptor    GlcNAc, N-acetylglucosamine    Gln, Glutamine    Glu, Glutamate    Gly, Glycine    HCP, Host cell protein    His, Histidine    ICH, International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use    IEF, Isoelectric focusing    IEX, Ion exchange chromatography    IND, Investigational new drug    IgG, Immunoglobulin    IsoAsp, Isoaspartate    LC-MS, Liquid chromatography-mass spectrometry    Lys, Lysine    MOA, Mechanism of action    Met, Methionine    NANA, N-acetylneuraminic acid    NGNA, N-Glycolylneuraminic acid    PD, pharmacodynamics    PK, Pharmacokinetics    PTM, posttranslational modifications    PyroGlu, Pyroglutamate    SEC-HPLC, Size exclusion chromatography-high performance liquid chromatography    Thr, Threonine    Trp, Tryptophan    cIEF, Capillary isoelectric focusing    comparability    mAb, Recombinant monoclonal antibody    pI, Isoelectric point    post-translational modifications    recombinant monoclonal antibodies   
期刊:MAbs  影响因子:4.405  发表日期: 20180320  PMID: 29513619 






OBJECTIVES: To describe the incidence, identification and management of common intraoperative com...

期刊:Arab J Urol  影响因子:0.0  发表日期: 20120301  PMID: 26558008 




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