lncRNA TUC338是一个膀胱癌潜在诊断生物标志物
尽管长的非编码RNA TUC338被表征为癌基因,但其在膀胱癌中的作用尚不清楚。本研究的目的是研究TUC338在膀胱癌中的功能。我们发现TUC338在早期膀胱癌患者中被上调,并显示出早期诊断价值。手术切除后,TUC338的血浆水平显着下调。此外,在膀胱癌患者中,microRNA 10b(miR-10b)也被上调。 TUC338和miR-10b在膀胱癌患者中呈阳性且显着相关,但在健康对照组中则不相关。 TUC338过表达的膀胱癌细胞显示miR-10b上调,而miR-10b过表达未能显着影响TUC338。 TUC338和miR-10b过表达显着促进膀胱癌细胞的侵袭和迁移。因此,TUC338可通过上调miR-10b至少部分地促进膀胱癌。**
lncRNA TUC338 is a potential diagnostic biomarker for bladder cancer
Although long noncoding RNA TUC338 has been characterized as an oncogene, its role in bladder cancer is unknown. The purpose of the present study is to investigate the function of TUC338 in bladder cancer. We found that TUC338 was upregulated in early-stage bladder cancer patients and showed early diagnostic values. After surgical resection, plasma levels of TUC338 were significantly downregulated. Moreover, microRNA 10b (miR-10b) was also upregulated in bladder cancer patients. TUC338 and miR-10b were positive and significantly correlated in bladder cancer patients, but not in healthy controls. Bladder cancer cells with TUC338 overexpression showed upregulated miR-10b, while miR-10b overexpression failed to significantly affect TUC338. TUC338 and miR-10b overexpression significantly promoted bladder cancer cell invasion and migration. Therefore, TUC338 may promote bladder cancer at least partially by upregulating miR-10b.
pmid: 31162712 J Cell Biochem 影响因子: 3.448 发表日期: 20190604 官网 免费下载