外泌体在食管癌中的研究进展
食道癌(EC)是人类最常见的消化道肿瘤之一,发病率和死亡率很高。有必要阐明癌症进展的机制,并寻求早期的EC诊断标记,以便及时发现和干预。外泌体是从许多直径为30-100 nm的有核细胞分泌的膜纳米囊泡,其中包含各种蛋白质,脂质和核酸。它们存在于外周血,尿液,腹水和其他体液中,广泛参与细胞间物质交换和信号通讯。 EC细胞或组织分泌的外泌体在肿瘤生长和进展中起重要作用。肿瘤来源或与肿瘤相关的外泌体的检测和分析具有潜在的EC早期诊断和预后评估的潜力。在本文中,综述了外泌体在EC进展中的生物学行为,分离,检测和功能-用作EC诊断或预后的潜在生物标记-。**
The research advances of exosomes in esophageal cancer
Esophageal carcinoma (EC) is one of the most common human digestive tract tumors, with high morbidity and mortality. It is necessary to elucidate the mechanism of cancer progression and seek early EC diagnostic markers for prompt detection and intervention. Exosomes are membrane nanovesicles secreted from many nucleated cells, 30-100 nm in diameter, containing various proteins, lipids and nucleic acids. They exist in peripheral blood, urine, ascites and other body fluids, widely engaged with intercellular material exchange and signal communication. Exosomes secreted from EC cells or tissues conduct important functions in tumor growth and progression. The detection and analysis of tumor-derived or tumor-associated exosomes has potential for EC early diagnosis and prognosis assessment. In the present paper, the exosomes' biological behaviors, isolation, detection and functions in EC progression - using as potential biomarkers for EC diagnosis or prognosis - are reviewed.
pmid: 31161775 Biomark Med 影响因子: 2.268 发表日期: 20190604 官网 免费下载
文献:

评论: