药草成分靶向骨肉瘤的抗癌效应
骨肉瘤是一种罕见的原发性骨恶性肿瘤,容易发生早期转移。切除手术和化学疗法是目前骨肉瘤的标准治疗方法。然而,由于转移的风险高,骨肉瘤患者的长期存活率低。因此,迫切需要一种新的方法来改善骨肉瘤的治疗。与化学疗法相比,从草药中分离出的天然活性成分显示出更少的不良反应和更好的抗肿瘤作用。这项研究旨在总结草药成分对骨肉瘤细胞进展和转移的抗癌作用。结果表明,草药的许多成分都可以通过靶向增殖,基质金属蛋白酶,整联蛋白和钙黏着蛋白以及血管生成来抑制骨肉瘤。该发现可能对开发新药和治疗策略有益。**
Anticancer Effects of Constituents of Herbs Targeting Osteosarcoma
Osteosarcoma is a rare primary malignancy of bone that is prone to early metastasis. Resection surgery and chemotherapeutic regimens are current standard treatments for osteosarcoma. However, the long-term survival rate of patients with osteosarcoma is low due to a high risk of metastasis. Hence, a new approach is urgently needed to improve the treatment of osteosarcoma. Compared with chemotherapy, natural active constituents isolated from herbs exhibit less adverse effects and better anti-tumor effects. This study aimed to summarize the anticancer effects of constituents of herbs on the progression and metastasis of osteosarcoma cells. It showed that many constituents of herbs inhibited osteosarcoma by targeting proliferation, matrix metalloproteinases, integrin and cadherin, and angiogenesis. The findings might be beneficial for the development of new drugs and treatment strategies.
pmid: 31161441 Chin J Integr Med 影响因子: 1.445 发表日期: 20190604 官网 免费下载
文献:

评论: