一种新的长链非编码RNA TONSL-AS1通过激活TONSL调控胃癌进展
据报道,长的非编码RNA(lncRNA)在各种恶性肿瘤中起重要作用,但它们在胃癌中的潜在功能尚不清楚。在这项研究中,我们发现一种名为TONSL-AS1的新型lncRNA与正常人相比在胃癌组织和细胞系中表达下调。 TONSL-AS1抑制SGC-7901,MGC-803细胞中的细胞迁移,侵袭和增殖。此外,TONSL-AS1可以在体内抑制细胞肿瘤发生。从机制上讲,TONSL-AS1的基因组邻近基因TONSL被报道为抑癌基因,它被上调。此外,TONSL-AS1与癌组织中的TONSL正相关。我们的研究表明,TONSL-AS1在胃癌细胞中的抑癌作用与TONSL有关。总的来说,我们的结果表明TONSL-AS1可作为抑癌基因lncRNA,可能是胃癌的新治疗靶点。**
A novel long non-coding RNA TONSL-AS1 regulates progression of gastric cancer via activating TONSL
Long non-coding RNAs (lncRNAs) are reported to play a significant role in various malignant tumors, yet their potential functions in gastric cancer are not clear. In this study, we found a novel lncRNA, named TONSL-AS1, was downregulated in gastric cancer tissues and cell lines compared with the normal. TONSL-AS1 inhibited cell migration, invasion and proliferation in SGC-7901, MGC-803 cells. Furthermore, TONSL-AS1 could suppress cell tumorigenesis in vivo. Mechanistically, TONSL-AS1's genomic neighboring gene TONSL, which was reported as a tumor suppress gene, was upregulated by TONSL. Additionally, the TONSL-AS1 was positively associated with TONSL in cancer tissues. Our study revealed that the tumor-inhibiting effect of TONSL-AS1 in gastric cancer cells was associated with TONSL. In general, our results indicated that TONSL-AS1 works as a tumor suppressor lncRNA, which may be a new therapeutic target for gastric cancer.
pmid: 31158361 Exp Cell Res 影响因子: 3.329 发表日期: 20190531 官网 免费下载
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