KRAS基因let-7 miRNA结合位点中的rs712多态性与墨西哥人群结肠直肠癌间的关联
目的: KRAS 基因的let-7 microRNA结合位点的rs712多态性与癌症有关。为了检查其与rs712多态性的关系,我们分析了患有结肠直肠癌(CRC)的墨西哥人和健康受试者。 材料与方法通过聚合酶链反应对281名对照和336名CRC患者进行rs712多态性的基因分型。 结果:观察到的rs712基因多态性表明存在相关的CRC保护因子( P = 0.032)。基因型与疾病之间的关联显而易见:结肠定位(等位基因 T,优势比(OR)3.82,95%置信区间(CI)2.77-5.28, P = 0.0001),淋巴结转移(基因型 TT, OR 2.49、95%CI 1.45-4.28, P = 0.0009),分化差(基因型GT,OR 2.35、95% CI 1.35-4.1, P = 0.0033),化疗反应不良(基因型GT,OR 2.6,95%CI 1.7-4.24, P = 0.0001)。 结论:与对照组患者的数据比较表明, KRAS 基因中rs712的多态性是保护因子,与CRC易感性有关。然而, KRAS 中rs712基因多态性的 TT GT 基因型可能对结肠定位,结节转移,分化差和化疗反应差有重要作用。该样本人群中的CRC患者。**
Association of rs712 polymorphism in a let-7 microRNA-binding site of KRAS gene with colorectal cancer in a Mexican population
Objectives: The rs712 polymorphism in a let-7 microRNA-binding site at KRAS gene has been associated with cancer. To examine its association with rs712 polymorphism, we analyzed Mexican individuals with colorectal cancer (CRC) and healthy subjects. Materials and Methods: Genotyping of the rs712 polymorphism was performed by polymerase chain reaction in 281 controls and 336 CRC patients. Results: The observed frequencies of rs712 polymorphism indicated an associated protective factor for CRC (P=0.032). An association between genotype and the disease was evident in: colon localization (allele T, odds ratio (OR) 3.82, 95% confidence Intervals (CI) 2.77-5.28, P=0.0001), node metastasis (genotype TT, OR 2.49, 95% CI 1.45-4.28, P=0.0009), poor differentiation (genotype GT, OR 2.35, 95% CI 1.35-4.1, P=0.0033), and poor chemotherapy response (genotype GT, OR 2.6, 95% CI 1.7-4.24, P=0.0001). Conclusion: Comparison of the data from patients with control group showed that polymorphism of rs712 in KRAS gene was protective factor, which was associated with susceptibility for CRC. However, the genotypes TT and GT of rs712 polymorphism in KRAS could contribute significantly to colon localization, node metastasis, poor differentiation and poor chemotherapy response in CRC patients in this sample population.
pmid: 31156795 Iran J Basic Med Sci 影响因子: 1.854 发表日期: 20190301 官网 免费下载
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