RHOA在胃癌中的作用:功能作用和治疗潜能
众所周知的信号介体和小的GTPase家族成员RHOA,现已与特定恶性肿瘤的进展相关。在这篇综述中,我们评估了有关这种酶在胃癌(GC)信号传导中作用的生物医学文献,暗示了潜在的临床意义。为此,我们针对第二代癌症检查了RHOA活性,发现其与“侵袭和转移的激活”标志特别相关。此外,大量研究表明,除了低分化的GC外,RHOA与Lauren分类弥散亚型相关。关于治疗价值,我们发现RHOA信号传导会影响广泛使用的特定化学疗法的活性,并可能受到各种饮食成分的拮抗作用。我们还将审查当前可用的针对GC的靶向疗法。然而,后者显示出这类药物的匮乏,强调迫切需要进一步研究这种高度致命的恶性肿瘤的治疗方法。**
RHOA in Gastric Cancer: Functional Roles and Therapeutic Potential
The well-known signal mediator and small GTPase family member, RHOA, has now been associated with the progression of specific malignancies. In this review, we appraise the biomedical literature regarding the role of this enzyme in gastric cancer (GC) signaling, suggesting potential clinical significance. To that end, we examined RHOA activity, with regard to second-generation hallmarks of cancer, finding particular association with the hallmark "activation of invasion and metastasis." Moreover, an abundance of studies show RHOA association with Lauren classification diffuse subtype, in addition to poorly differentiated GC. With regard to therapeutic value, we found RHOA signaling to influence the activity of specific widely used chemotherapeutics, and its possible antagonism by various dietary constituents. We also review currently available targeted therapies for GC. The latter, however, showed a paucity of such agents, underscoring the urgent need for further investigation into treatments for this highly lethal malignancy.
pmid: 31156701 Front Genet 影响因子: 3.517 发表日期: 20190101 官网 免费下载
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