评估SGO1和SGO1-AS1在乳腺癌中的贡献
Shugoshin样蛋白1(SGO1)参与有丝分裂的适当进程。这种基本作用表明该基因在癌症的发病机理中作为有丝分裂细胞分裂障碍的重要性。先前对肺癌中长非编码RNA(lncRNA)表达进行的高通量研究已确定了这些标本中SGO1-反义1(SGO1-AS1)的异常表达。在本研究中,我们量化了SGO1和SGO1-AS1在39个乳腺癌组织及其配对的相邻非癌组织(ANCT)中的表达。与ANCT相比,SGO1-AS1在肿瘤组织中的表达明显降低(表达比= 0.49,P值= 0.03)。但是,我们无法确定这两组标本之间SGO1表达的显着差异(表达比= 2.9,P值= 0.2)。 SGO1-AS1的转录本数量与疾病发作的年龄有关(P = 0.01)。任一基因的表达都与激素受体状态或临床特征(例如等级和阶段)有关。两组样品中基因的表达之间呈负相关。最后,SGO1-AS1的转录物数量可以区分这两组样品,准确度为63%(P值= 0.03)。我们的结果表明,SGO1-AS1在乳腺癌中具有重要意义,因此有必要进行机理研究以找到这方面的分子途径。**
Assessment of SGO1 and SGO1-AS1 contribution in breast cancer
Shugoshin-like protein 1 (SGO1) participated in the proper progression of mitosis. This fundamental role has indicated the importance of this gene in the pathogenesis of cancer as a disorder of mitotic cell division. A previous high throughput study of long non-coding RNAs (lncRNAs) expression in lung cancer has identified aberrant expression of SGO1-antisense 1 (SGO1-AS1) in these specimens. In the current study, we quantified expression of SGO1 and SGO1-AS1 in 39 breast cancer tissues and their paired adjacent non-cancerous tissues (ANCTs). Expression of SGO1-AS1 was considerably decreased in tumoral tissues compared with ANCTs (expression ratio = 0.49, P value = 0.03). However, we could not identify significant difference in expression of SGO1 between these two sets of specimens (expression ratio = 2.9, P value = 0.2). Transcript quantities of SGO1-AS1 were associated with age at disease onset (P= 0.01). Expression of either gene was associated with hormone receptors status or clinical features such as grade and stage. There was an inverse correlation between expressions of genes in both sets of samples. Finally, transcript amounts of SGO1-AS1 could distinguish these two sets of samples with accuracy of 63% (P value = 0.03). Our results imply significance of SGO1-AS1 in breast cancer and necessitate conduction of mechanistic studies to find the molecular pathways in this regard.
pmid: 31156154 Hum Antibodies 影响因子: 0.0 发表日期: 20190524 官网 免费下载
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